Misuse and overuse of antimicrobials in humans and livestock has led to the emergence of antimicrobial resistant bacterial strains compromising the effectiveness of antimicrobial therapy. They have been used to treat and prevent microbial infections in human and veterinary medicine for decades. Hospital effluents contained more of MDR bacteria, posing significant public health threat through dissemination to the downstream water bodies.Īntimicrobials are natural or synthetic chemicals that kill or inhibit the growth of susceptible microorganisms. The present study revealed that Enterobacteriaceae in wastewater from hospitals, abattoir and downstream water bodies are resistant to commonly used antimicrobials. Extended spectrum betalactamase (ESBL) production was detected in 27.3% of MDR isolates, all of them obtained from hospital effluents whereas none of the isolates were carbapenemase producers.
Multi-drug resistance (MDR) to several antimicrobials was recorded, particularly in isolates obtained from hospital WWS and it was more common in Citrobacter and E.
All isolates were resistant to 2 or more antimicrobials tested. coli isolate from the same source was resistant to 11 antimicrobials. isolated from TASH wastewater sample (WWS) were resistant to all 12 antimicrobials tested whereas an E. ResultsĪ total of 54 bacterial isolates belonging to 6 species were identified: E.coli (32%), Salmonella 23%), Klebsiella pneumonia (15%), Enterobacter aerogenes (11%), Citrobacter (7%), Klebsiella oxytoca (6%) and Enterobacter cloacae (6%), respectively. The present study assessed antimicrobial susceptibility of bacteria belonging to the family Enterobacteriaceae isolated from wastewater samples (WWS) of two hospitals: Tikur Anbessa Specialized Hospital (TASH) and Minilik II hospital, a wastewater treatment plant (WWTP) and an abattoir, and downstream rivers in Addis Ababa. There is limited information about antimicrobial susceptibility profile of common Enterobacteriaceae in waste water samples from hospitals, abattoirs and the downstream water bodies in Addis Ababa. Evaluation of antimicrobial susceptibility profile of various bacterial pathogens in the health facilities, abattoirs and related environment is important to assess potential risk of dissemination of resistant pathogens to the environment.
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